WebJun 19, 2024 · Read-Across Methodology in Toxicological Risk Assessment Introduction. Chemical risk assessment aims at compound-specific threshold values, like acceptable … WebRead-across is one of the most frequently used alternative tools for hazard assessment, in particular for complex endpoints such as repeated dose or developmental and reproductive toxicity. Read-across extrapolates the outcome of a specific toxicological in vivo endpoint from tested (source) compounds to "similar" (target) compound (s).
Bibra Read-Across
WebAug 1, 2015 · Within the applicability domain of a chemical category, read-across can be performed to fill data gaps with a number of approaches which can be summarised into the following four techniques: (1) one-to-one read-across (i.e., one source substance used to make a prediction for a single target chemical), (2) WebToxicology Letters 116(S1), 61. Potts RO, Guy RH. (1992). Predicting skin permeability. ... The UK Environmental Agency have a similar approach to read across as the HSE though appropriate ecotoxicity tests such as acute toxicity to Daphnia form the basis of establishing the validity of their read acrosses.The approach is also a step-by-step ... floating point to ieee 754
Molecular Similarity in Computational Toxicology SpringerLink
WebJun 23, 2024 · The concept of chemical similarity has many applications in several fields of cheminformatics. One common use of chemical similarity measurements, based on the principle that similar molecules have similar properties, is in the context of the read-across approach, where estimates of a specific endpoint for a chemical are obtained starting … WebRead-across (RAx) translates available information from well-characterized chemicals to a substance for which there is a toxicological data gap. The OECD is working on case … Web• Computational toxicologist expert in in silico chemical safety assessment • Professional expertise in generating (eco)toxicological and physicochemical data by means of in silico approaches (QSAR, expert systems and read-across) in compliance with the current regulations (e.g., REACH, CLP, ICH M7 guideline, Biocides and Cosmetics … floating points printworks