WebCollagen type IV is the most abundant constituent of the basement membrane, and is essential for structural maintenance. Despite expression of six collagen type IV α-chains, only three sets of heterotrimers are identified in tissues. Collagen. Collagen is a family of extracellular molecules that are exposed … Laminin is a protein that shares several properties with fibronectin. For example, … Type IV collagen forms a flexible open network by association through both the … It appears to be a disease of the adult GBM type IV collagen trimer α3:α4:α5. … WebCollagen type IV is the major structural element of basal membranes. Human collagen type IV is a native triple helix. Collagen was extracted from washed dissected tissue into …
Basement Membrane Type IV Collagen and Laminin: An …
WebFeb 15, 1993 · Our data demonstrate that the NC1 and COL1 domains of type XII collagen contain the information necessary for trimer formation and that, contrary to the fibrillar collagen types, posttranslational modification of the triple helical domain is essential for assembly and disulfide bonding of the chains. WebFeb 27, 2024 · Type IV collagen is a ubiquitous component of basement membranes along with laminin, entactin/nidogen, and heparan sulfate proteoglycans. Six type IV collagen genes (COL4A1–COL4A6) encode six unique alpha chains of type IV collagen [α1(IV)–α6(IV)].Mutations in several of the type IV collagen genes can cause a number … change for life advertising
ALPORT SYNDROME: ABNORMALITIES OF TYPE IV COLLAGEN …
WebDec 8, 2024 · Part of collagen type IV trimer. Is expressed in glomerular tuft and testis. Used to study autosomal recessive Alport syndrome. Human ortholog(s) of this gene implicated in autosomal recessive Alport syndrome; benign familial hematuria; and end stage renal disease. Orthologous to human COL4A4 (collagen type IV alpha 4 chain). WebFeb 19, 2024 · Col4a-2. Summary. This gene encodes the alpha-2 subunit of the type IV collagens, an essential component of basement membranes. The encoded protein forms a triple helical heterotrimer comprised of alpha-1 and alpha-2 subunits that assembles into a type IV collagen network. Canstatin, a peptide derived fom the C-terminus of the … WebDec 8, 2024 · Predicted to be an extracellular matrix structural constituent. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway and neuromuscular junction development. Located in basement membrane and neuromuscular junction. Part of collagen type IV trimer. Is expressed in several structures, including alimentary system ... change for life food scanner app