Circhectd1
WebExpression of circHECTD1 in macrophages after exposure to SiO 2. Based on accumulating evidence, alveolar macrophages (AMOs) are the effector cells of silicosis [3, 5, 20].AMOs are the most important immune barrier against invading pathogens and environmental contaminants in pulmonary innate immunity [14, 21].Thus, the effect of … WebcircHECTD1 in IS. qRT-PCR and western blot were used to test gene and protein expressions, respectively. CCK-8 assay was used to investigate the cell viability. Moreover, cell migration and tube formation were assessed by transwell and tube formation assays. In addition, RIP and luciferase assay were performed to explore the association among ...
Circhectd1
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WebSep 1, 2024 · The relationships between circHECTD1, miRNAs, and target genes were assessed by RNA pull-down, luciferase reporter gene, and RNA-FISH assays. circHECTD1 was downregulated in LPS-induced human and mouse AECs (HBE and MLE-12). The knockdown of circHECTD1 increased the apoptotic rates and the expressions of miR … WebJan 20, 2024 · In summary, circHECTD1 knockdown significantly alleviated EndoMT process in HCMECs via mediation of miR-335/NOTCH2 axis. Thus, circHECTD1 might act as a potential target against IS. Ischemic stroke (IS) has become a cerebrovascular disease which seriously threatens the elderly people. It has been reported that circRNAs …
WebAs shown in Fig. 4a, b, specific knockdown of circHECTD1 using siRNAs sig- nificantly inhibited the SiO 2 -induced decreases in VE-Cad/ Cdh-5 and PECAM 1/CD31 expression and the increases in Col ... WebSep 1, 2024 · The knockdown of circHECTD1 increased the apoptotic rates and the expressions of miR-136 and miR-320a, while its overexpression caused opposite effects in LPS-induced HBE and MLE-12 cells. Mechanistically, circHECTD1 bound to miR-320a and miR-136. miR-320a targeted PIK3CA and mediated the effect of circHECTD1 on …
WebMay 17, 2024 · CircHECTD1 Lentivirus, miR-320-5p mimic, and SLC2A1 Lentivirus were transduced into cancer cells independently or together. circHECTD1, miR-320-5p, and SLC2A1 level were detected by qRT-PCR. WebcircHECTD1 or PBX3 was expounded by dual-luciferase reporter, RNA immunoprecipitation (RIP) and RNA pull down assays. Results: We uncovered that circHECTD1 was ectopically up-regulated in GC tissues and cells. CircHECTD1 deciency sensitized DB-treatment in DB-evoked AGS and HGC-27 cells. In vivo assay, circHECTD1 silencing led to the tumor ...
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WebAug 2, 2024 · Our results revealed that circHECTD1 is a glutaminolysis-associated circRNA that promotes GC progression. The circHECTD1/miR-1256/USP5 axis could thus be used as a therapeutic target for GC. northern neck va prisonWebDec 21, 2024 · Circular RNA circHECTD1 facilitates glioma progression by regulating the miR-296-3p/SLC10A7 axis. The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1. CircHECTD1 up-regulates mucin 1 expression to accelerate hepatocellular carcinoma development by targeting microRNA-485-5p via a competing … northern network for medical humanitiesWeb2 circHECTD1 attenuates apoptosis of alveolar epithelial cells in acute lung injury.. 来源：lab invest( P 0023-6837 E 1530-0307 ) 发表时间: 2024/09. 类型：期刊论文 为本人加分 northern networkingWebZestimate® Home Value: $318,000. 2401 Fairway Cir, Mitchell, SD is a single family home that contains 1,531 sq ft and was built in 1991. It contains 4 bedrooms and 1.75 … northern netherlandsWebCircular RNAs (circRNAs) play important roles in many lung diseases. This study aimed to investigate the role of circHECTD1 in acute lung injury (ALI). The mouse and cell models of ALI were induced by lipopolysaccharide (LPS). The apoptosis of alveolar epithelial cells (AECs) was detected by flow cytometry. The relationships between circHECTD1, … northern neutral zone stableWebcircHECTD1 facilitated the proliferation, migration, and invasion of GC cells. circHECTD1 enhances glutaminolysis in GC The effects of circHECTD1 on glutaminolysis were further explored. We ... northern network of peers for equalityWebMay 17, 2024 · CircHECTD1 knockdown suppressed GC tumor growth in vivo. Nude mice were injected with lentivirus-mediated AGS cells with sh-circHECTD1 or sh-NC treatment. a QRT-PCR analysis for the expression of ... how to run a gang